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doi: 10.3389/fimmu.2017.01438 Received 24 January 2017 Accepted 16 October 2017 Published 06 November 2017 Volume 8 - 2017 Edited by Luigi Daniele Notarangelo, Boston Childrens Hospital, United States Reviewed by Stasya Zarling, Walter Reed Army Institute of Research, United States